Suggestions
There is no single right way to lay out a drawing. Here are a few starting points to try as you get comfortable with Redline.
Give the drawing room
Let automatic routing do the first pass, then adjust paths where it helps the reader follow a connection. Flags can replace long routes or carry a connection between sheets.
Try placing flags close to their ports with short, straight leads. Leave room for the text at both ends, especially when several flags sit together.
Connections and routes and Flags on edges cover the controls.
Choose a comfortable sheet scale
Two grid squares per centimeter gives each square 5 mm on paper. Start there, then export a page to see whether its labels are comfortable to read at the size you expect people to use. A denser page fits more, but makes everything smaller.
Pages and drawing scale explains page density.
Let each kind of information have a home
An annotation is text placed on the drawing. Use one for information the reader needs nearby. User fields are named values attached to an item; they can also appear in tables. Frontmatter holds sheet details in the title block. A light background can group related items without another large heading.
Make a table from information you already have
Add a Manual URL user field to a few devices, then make a device table with ID, Label, and that user field. Or add a sheet index that follows page names as the project grows. See Generated project tables.
Adding metadata to many devices is a good use for agents. It's naturally repetitive and you can verify its correctness by looking at the resulting table. See Working with agents.
Reuse an arrangement
Reusable blueprints can hold a device or a connected group with annotations and backgrounds. Try saving a small arrangement you often repeat, then adapt each placement to its new location.
Check the finished sheets
An export is a useful way to review the drawing at reading size. Look at both the whole sheet and a detail: can you follow connections, read the small labels, and find the next page of a table?